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KMID : 0370220190630060390
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Yakhak Hoeji
2019 Volume.63 No. 6 p.390 ~ p.398
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Gender Disparity of EMT-related Gene Expression Affects survival of Hepatocellular Carcinoma Patients
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Song Hye-Kyung
Kim Sun-Young
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Abstract
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Cancer development and malignancy are caused by changes in expression levels of genes and proteins due tovarious factors, resulting in poor quality of life and shortened lives. Gender-induced differences such as hormones andactivation of their receptors can also contribute to cancer development and malignancy in addition to external factors. Toexplore these correlations between gender and cancer malignancy, we investigated expression levels of epithelial-tomesenchymaltransition (EMT)-related genes with gender disparity and their risks in relation to the overall survival ofhepatocellular carcinoma patients using public databases including RNA sequencing data. Correlations between theexpression of EMT-related gene selected in previously published literature and overall survival of male and femalehepatocellular patients were statistically analyzed and shown as Kaplan-Meier survival curves using public databases fromthe Gene Expression Omnibus (GEO), the European Genome-phenome Archive (EPA), and The Cancer Genome Atlas(TCGA). Of genes analyzed, five transcription factors, two post-transcriptional regulators, and two post-translationalregulators involved in EMT regulation showed different hazard ratios depending on gender in hepatocellular carcinomapatients. Taken together, these results demonstrate that the gender of hepatocellular patients might affect the regulation ofEMT-related gene expression and cancer malignancy, leading to shortened overall survival.
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KEYWORD
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Gender, Hepatocellular carcinoma, EMT, Gene expression, Survival
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